宋文（博士），海南大学生物医学工程学院副研究员，硕、博导师。2019年博士毕业于武汉大学化学与分子科学学院，2022年12月加入海南大学生物医学工程学院。海南自由贸易港D类人才，三亚崖州湾科技城D类人才。
研究方向：
1. 抗肿瘤药物载体构建与应用
2. 肿瘤免疫治疗效果评估与成像
3. 细胞代谢调节及应用
招生需求：
欢迎具有生物学、医学、化学、材料学等相关背景的同学加入
联系方式：[email protected]
代表论文：
1. Fu, Z.; Cui, X.; Liu, S.; Gao, L.; Sun, Y.; Chen, Y.; Li, M.; Fan, Y.; Kuang, J.; Song, W.*; Zhou, F*. Photo-Empowered Macrophage-Based Drug Delivery System Overcomes Motility Suppression and Significantly Enhances Deep Tumor Drug Delivery. Adv Sci 2026, 13, e15349.
2. Huang, S.; Gao, L.; Chen, Y.; Fu, Z.; Wang, Z.; Liu, Y.; Zhou, Z.; Huang, R.; Song, W.*; Zhou, F. A versatile nanoplatform for enhancing the therapeutic efficacy against low-immunogenic TNBC by inducing immunogenic cell death and MHC-I upregulation. Mater Today Bio 2026, 37, 102927.
3. Yuan, L.; Yang, L.; Song, W.; Song, H.; Hu, J.-J*.; Lou, X*.; Xia, F.; Yoon, J. Photochemical Generation of Peroxynitrite: Concurrent Inhibition of Glycolysis and Glutamine Metabolism for Enhanced Metabolic Therapy. J Am Chem Soc 2025, 147, 32610-32624.
4. Liu, S.; Sun, Y.; Yan, D*.; Song, W.; Fu, J.; Wang, S.; Yang, T.; Zhu, J.; Zhu, D.; Wang, D*.; Zhou, F*.; Tang, B. Z. A relay-type innate immunity activation strategy involving water-soluble NIR-II AIEgen for boosted tumor photo-immunotherapy. Theranostics 2024, 14 (12), 4667-4682.
5. Hu, J. J.; Yuan, L.; Zhang, Y.; Kuang, J.; Song, W.; Lou, X*.; Xia, F.; Yoon, J*. Photo-Controlled Calcium Overload from Endogenous Sources for Tumor Therapy. Angew Chem Int Ed Engl 2024, 63 (9), e202317578.
6. Fu, Z.; Feng, M.; Wu, J.; Liu, B.; Fu, J.; Song, W*. Photodynamic Therapy Synergizes CD47 Blockade Strategy for Enhanced Antitumor Therapy. Mol Pharmaceutics 2024, 21 (8), 3897-3908.
Selected publications before HNU：
1. Song, W.; Yang, F.; Yang, H.; Xu, Y.; Song, S. J.; Meng, Y.; Wei, S. T.; Wan, T.; Zhou, Y.; Zhou, B.; Kuang, J*.; Yu, T*.; Qiu, W. X*. Enhanced Immunotherapy Based on Combining the Pro-phagocytosis and Anti-phagocytosis Checkpoint Blockade for Tumor Eradication. J Med Chem 2022, 65 (21), 14832-14842.
2. Song, W.; Song, S. J.; Kuang, J.; Yang, H.; Yu, T.; Yang, F.; Wan, T.; Xu, Y.; Wei, S. T.; Li, M. X.; Xiong, Y*.; Zhou, Y*.; Qiu, W. X*. Activating Innate Immunity by a STING Signal Amplifier for Local and Systemic Immunotherapy. ACS Nano 2022, 16 (10), 15977-15993.
3. Song, W.; Hu, J. J.; Song, S. J.; Xu, Y.; Yang, H.; Yang, F.; Zhou, Y*.; Yu, T*.; Qiu, W. X*. Aptamer-Gold Nanocage Composite for Photoactivated Immunotherapy. ACS Appl Mater Interfaces 2022, 14 (38), 42931-42939.
4. Chen, A.; Yang, F.; Kuang, J.; Xiong, Y.; Mi, B. B.; Zhou, Y.; Hu, J. J.; Song, S. J.; Wan, T.; Wan, Z. Z.; Huang, H. Y.; Li, X. R.; Song, W*.; Qiu, W. X*. A Versatile Nanoplatform for Broad-Spectrum Immunotherapy by Reversing the Tumor Microenvironment. ACS Appl Mater Interfaces 2021, 13 (38), 45335-45345.
5. Zheng, D. W.; Gao, F.; Cheng, Q.; Bao, P.; Dong, X.; Fan, J. X.; Song, W.; Zeng, X.; Cheng, S. X.; Zhang, X. Z*. A vaccine-based nanosystem for initiating innate immunity and improving tumor immunotherapy. Nat Commun 2020, 11 (1), 1985.
6. Zheng, D. W.; Hong, S.; Zhang, Q. L.; Dong, X.; Pan, P.; Song, W. F.; Song, W.; Cheng, S. X.; Zhang, X. Z*. Controllable gelation of artificial extracellular matrix for altering mass transport and improving cancer therapies. Nat Commun 2020, 11 (1), 4907.
7. Liu, W. L.; Zou, M. Z.; Liu, T.; Zeng, J. Y.; Li, X.; Yu, W. Y.; Li, C. X.; Ye, J. J.; Song, W.; Feng, J*.; Zhang, X. Z*. Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells. Nat Commun 2019, 10 (1), 3199.
8. Zhang, C.; Zhang, L.; Wu, W.; Gao, F.; Li, R. Q.; Song, W.; Zhuang, Z. N.; Liu, C. J.; Zhang, X. Z*. Artificial Super Neutrophils for Inflammation Targeting and HClO Generation against Tumors and Infections. Adv Mater 2019, 31 (19), e1901179.
9. Kuang, J.; Song, W.; Yin, J.; Zeng, X.; Han, S.; Zhao, Y. P.; Tao, J.; Liu, C. J*.; He, X. H*.; Zhang, X. Z. iRGD Modified Chemo-immunotherapeutic Nanoparticles for Enhanced Immunotherapy against Glioblastoma. Adv Funct Mater 2018, 28 (17), 1800025.
10. Song, W.; Kuang, J.; Li, C. X.; Zhang, M.; Zheng, D.; Zeng, X.; Liu, C*.; Zhang, X. Z*. Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication. ACS Nano 2018, 12 (2), 1978-1989.
专利：
1. 宋文; 范雨昕; 周非凡，一种用于光热免疫治疗的介孔聚多巴胺纳米复合物、制备方法及其应用，CN121177469A 发明公开
2. 周非凡、刘波、宋文，一种包载纳米颗粒的水凝胶及其制备方法与应用，CN118948748A 发明公开
3. 周非凡; 杨景; 宋文，一种基于巨噬细胞的光驱动型药物及其应用，CN118949055A 发明公开
4. 周非凡; 符佳佳; 宋文，一种光疗实验装置，CN118902665A 发明公开
5. 周非凡、冯明辉、宋文、宋瑞祥，用于动物背部皮窗活体成像的固定成像装置，CN 220001733 U 已授权
主持科研项目：
1. 海南省重点研发项目，ZDYF2024SHFZ068，202402-202702，48万，在研，主持
2. 国家自然科学基金地区科学基金项目，22365014，202401-202712，31万，在研，主持
3. 国家自然科学基金青年科学基金项目，52003210，202101-202312，30万，已结题，主持
4. 中国博士后科学基金 67 批面上资助二等，2020M672423，202009-202206，8万，已结题，主持
